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viagra (sildenafil)

The preparation recovers the normal reaction to sexual arousal

viagra (sildenafil)

Pharmacological action:

The preparation recovers the normal reaction to sexual arousal. A physiological mechanism that ensures an erection is not possible without emitting of nitric oxide in cavernous body during sexual stimulation. NO activates a special enzyme called guanylate cyclase, as a result the level of cycle guanosine monophosphate (cGMP) is increased, muscles of the cavernous body relax and the blood flow is increased in a penis. Sildenafil, the active ingredient of VIAGRA, is selective inhibitor of PDE5 (phosphodiesterase type 5) that ensures the collapse of cGMP in the cavernous body. The drug is characterized by a peripheral effect on penile erection. It is noteworthy that sildenafil relaxes the cavernous body not directly, but by means of relaxing function of nitric oxide. It is known that the sexual stimulation is needed for a useful pharmacological action. The drug is well tolerated, healthy volunteers did not reported about clinically significant deviations at single taking in amount not more than 100 mg.

Indication for use:

The drug is prescribed at erectile dysfunctions (as a rule, psychogenic, organic and mixed).

Method of use:

Tablets are taken orally, approximately one hour before planned sexual intercourse. The optimal single dose for adults is 50 mg once a day. Taking into consideration the individual tolerance and efficacy of the drug, the dose may be reduced to 25 mg or increased to 100 mg. The maximum single dose is 100 mg per day. The standard dose should not be changed for elderly.

Side effects:

The medicine is well tolerated. In some cases were observed side effects:

  • central nervous system (insomnia, dizziness and rise of muscular tonus)
  • cardio-vascular system (afflux, headache, vasodilation)
  • musculoskeletal system (pain in the joints and muscles)
  • gastrointestinal tract (nausea, diarrhea, dyspepsia)
  • skin (rash)
  • sensory organs (conjunctivitis, violation of vision clarity, increased light perception, change of color perception)
  • organs of the respiratory system (respiratory distress, pharyngitis, sinusitis, rhinitis, nasal congestion, respiratory tract infection)
  • urogenital system (disorder of prostate, infection urinary channels)

Other side effects included symptoms of influenza, back pain or stomach. Cases of priapism were reported rare.

Contraindications:

The medicine is contraindicated to patients with hypersensivity to the components of the medicine and with the deformation of a penis (Peyronie's disease, cavernous fibrosis, angulation). Also this drug should not be taken in the following disorders:

  • increased tendency to bleeding
  • acute stage of ulcer disease of the gastrointestinal tract
  • disorders of the liver, especially severe renal failure or cirrhosis
  • diseases that develop priapism, including leukemia, multiple myeloma and sickle cell anemia
  • severe hypotension or hypertension
  • various heart diseases, including unstable angina, arrhythmia in dangerous form and cardiac insufficiency

If the patient has suffered stroke or myocardial infarction, the drug should not be used the next six months. Also, Viagra is not administered to children. It is strictly forbidden simultaneously using this drug with nitrates and donors of nitric oxide. Viagra should not be prescribed to men whom are contraindicated sexual activity.

Pregnancy:

This drug is not prescribed to women. As the result of the reproductive experiments on rabbits and rats it was revealed that there is no teratogenic effect of Viagra. The fetus has developed without deviations and disorders. Also the morphology and activity of sperm of volunteers was investigated at a single dose of the drug taking. No deviations have been found.

Interaction with other medicines:

The administration of erythromycin, cimetidine and ketoconazole is characterized by decrease of clearance and subsequent increase of sildenafil content in blood plasma. Coadministration of Viagra and sodium nitroprusside enhances its antiaggregant (antiplatelet) effect. Viagra enhances the hypotensive effect of drugs containing nitrates. This may lead to death. Also dangerous to life simultaneous reception of the drug with oral hypoglycemic drugs, calcium channel inhibitors and beta- adrenoceptor blocking drugs.

Overdose:

The research has shown that the adverse effects were manifested more obviously at the overdose. Only symptomatic therapy can be applied for the treatment. Dialysis is not effective because the active ingredient actively and rapidly is bound with the proteins of blood plasma.

Delivery form:

Viagra is produced in the form of firm-coated tablets. The tablets are in the aluminum blister that is in carton package.

Storage conditions:

Viagra should be stored in a cool dry place, away from children. The storage temperature should not exceed 30 °C. The shelf-life is 2 years. It is prohibited to administrate expired medicine.

Synonyms:

Sildenafil

Ingredients:

Main active ingredient is Sildenafil in the form of citrate. The inactive ingredients are anhydrous calcium phosphate, magnesium stearate, croscarmellose sodium, titanium dioxide (E 171), triacetin, hypromellose, FD&C Blue aluminum lake (E 132), lactose.

Additionaly:

The drug is put on prescription.

Attention!

The description of the medicine Viagra at this page is the simplified and supplemented version of the official instructions. In any case you should consult a doctor and to read carefully the instructions of the producer before use of the preparation. The information about the medicine is presented only for the purpose of familiarization and cannot be used as the instructions for self-treatment. Only a doctor is authorized to prescribe the medicine and also to determine the dose and method of use.